1,428 research outputs found
Is the C-terminal flanking peptide of rat cholecystokinin double sulphated?
AbstractA specific radioimmunoassay was developed to the predicted nine amino acid C-terminal flanking peptide of cholecystokinin (peptide serine serine, PSS). In aqueous extracts of rat brain, PSS was undetectable unless the extracts were first treated with arylsulphatase, which also resulted in desulphation of cholecystokinin. The reverse-phase HPLC analysis of partially desulphated extracts showed the presence of two peaks intermediate to the naturally occurring and the completely desulphated forms. It is therefore proposed that the CCK-flanking peptide PSS has both tyrosine residues sulphated
Regions from the ground up: a network partitioning approach to regional delineation
In this paper, we consider the question of what is ‘in’ a region, from an economic perspective, based on commuting data. This follows a long line of studies on labour market delineation, including the widely used ‘travel-to-work area’ approach. Using Combo, a network partitioning algorithm, we analyse commuting data from the 2011 UK Census in order to define a discrete set of regions. Our aim is twofold: to contribute to methodological advances in regional delineation, and to produce results that have real-world utility. Following the introduction, we review previous work, before describing our data and methods. Our approach produces 17 new ‘regions’ for Scotland, in contrast to the existing set of 32. Our view is that algorithmic approaches to regional delineation have much to offer in a policy setting, but this must be tempered by the fact that regions, however defined, are inherently political constructs
Beyond locutionary denotations: exploring trust between practitioners and policy
This study reports the findings of a research on the trust relationship between practitioners in the Skills for Life (SfL) area and the policy that informs their practice. The exploration of this relationship was premised on an extended notion of trust relationship which draws from the Speech Act theory of Austin (1962; Searle 1969; Kissine 2008), leading to the claim that the existence of different layers of imports in textual analysis makes it possible for a trust relationship to exist between the human/physical and the non human/non physical. The study found that the majority of practitioners in the SfL field trust policy to deliver its inherent policy only to a limited extent. Amongst others, the study identified the impact of the perlocutionary import of policy text on practitioners as a viable reason for this limited level of trust. Such perlocutionary imports, it also found, have adverse impact on practitioners who are considered to have drawn from previous experience to mediate the import of contemporary policies
Interaction of desulfovibrio desulfuricans biofilms with stainless steel surface and its impact on bacterial metabolism
Aims: To study the influence of some metallic elements of stainless steel 304 (SS 304) on the development and activity of a sulfate-reducing bacterial biofilm, using as comparison a reference nonmetallic material polymethylmethacrylate (PMMA).
Methods and Results: Desulfovibrio desulfuricans biofilms were developed on SS
304 and on a reference nonmetallic material, PMMA, in a flow cell system.
Steady-state biofilms were metabolically more active on SS 304 than on PMMA. Activity tests with bacteria from both biofilms at steady state also showed that the doubling time was lower for bacteria from SS 304 biofilms.
The influence of chromium and nickel, elements of SS 304 composition, was
also tested on a cellular suspension of Des. desulfuricans. Nickel decreased the bacterial doubling time, while chromium had no significant effect.
Conclusions: The following mechanism is hypothesized: a Des. desulfuricans
biofilm grown on a SS 304 surface in anaerobic conditions leads to the weakening
of the metal passive layer and to the dissolution in the bulk phase of nickel ions that have a positive influence on the sulfate-reducing bacteria metabolism.
This phenomenon may enhance the biocorrosion process.
Significance and Impact of the Study: A better understanding of the interactions between metallic surfaces such as stainless steel and bacteria commonly implied in the corrosion phenomena which is primordial to fight biocorrosion.Programme Praxis XXI; University of Santiago de
Compostela
Mild parenchymal lung disease and/or low diffusion capacity impacts survival and treatment response in patients diagnosed with idiopathic pulmonary arterial hypertension
There are limited published data defining survival and treatment response in patients with mild lung disease and/or reduced gas transfer who fulfil diagnostic criteria for idiopathic pulmonary arterial hypertension (IPAH).
Patients diagnosed with IPAH between 2001–19 were identified in the ASPIRE registry. Using pre-specified criteria based on CT imaging and spirometry, patients with a diagnosis of IPAH and no lung disease were termed IPAHno-LD (n=303), and those with minor-mild emphysema or fibrosis were described as IPAHmild-LD (n=190).
Survival was significantly better in IPAHno-LD than in IPAHmild-LD (1 and 5-year survival 95% and 70% versus 78% and 22% respectively, p<0.0001). In the combined group of IPAHno-LD and IPAHmild-LD, independent predictors of higher mortality were increasing age, lower DLCO, lower exercise capacity and a diagnosis of IPAHmild-LD (p all <0.05). Exercise capacity and quality of life improved (p both <0.0001) following treatment in patients with IPAHno-LD but not IPAHmild-LD. A proportion of patients with IPAHno-LD had a DLCO <45%; these patients had poorer survival than patients with DLCO ≥45% although demonstrated improved exercise capacity following treatment.
The presence of even mild parenchymal lung disease in patients who would be classified as IPAH according to current recommendations has a significant adverse effect on outcomes. This phenotype can be identified using lung function testing and clinical CT reports. Patients with IPAH, no lung disease and severely reduced DLCO may represent a further distinct phenotype. These data suggest that RCTs of targeted therapies in patients with these phenotypes are required
The Magnetic Field of the Solar Corona from Pulsar Observations
We present a novel experiment with the capacity to independently measure both
the electron density and the magnetic field of the solar corona. We achieve
this through measurement of the excess Faraday rotation due to propagation of
the polarised emission from a number of pulsars through the magnetic field of
the solar corona. This method yields independent measures of the integrated
electron density, via dispersion of the pulsed signal and the magnetic field,
via the amount of Faraday rotation. In principle this allows the determination
of the integrated magnetic field through the solar corona along many lines of
sight without any assumptions regarding the electron density distribution. We
present a detection of an increase in the rotation measure of the pulsar
J18012304 of approximately 160 \rad at an elongation of 0.95 from
the centre of the solar disk. This corresponds to a lower limit of the magnetic
field strength along this line of sight of . The lack of
precision in the integrated electron density measurement restricts this result
to a limit, but application of coronal plasma models can further constrain this
to approximately 20mG, along a path passing 2.5 solar radii from the solar
limb. Which is consistent with predictions obtained using extensions to the
Source Surface models published by Wilcox Solar ObservatoryComment: 16 pages, 4 figures (1 colour): Submitted to Solar Physic
Quaternion-Octonion Unitary Symmetries and Analogous Casimir Operators
An attempt has been made to investigate the global SU(2) and SU(3) unitary
flavor symmetries systematically in terms of quaternion and octonion
respectively. It is shown that these symmetries are suitably handled with
quaternions and octonions in order to obtain their generators, commutation
rules and symmetry properties. Accordingly, Casimir operators for SU(2)and
SU(3) flavor symmetries are also constructed for the proper testing of these
symmetries in terms of quaternions and octonions
Motion of influential players can support cooperation in Prisoner's Dilemma
We study a spatial Prisoner's dilemma game with two types (A and B) of
players located on a square lattice. Players following either cooperator or
defector strategies play Prisoner's Dilemma games with their 24 nearest
neighbors. The players are allowed to adopt one of their neighbor's strategy
with a probability dependent on the payoff difference and type of the given
neighbor. Players A and B have different efficiency in the transfer of their
own strategy therefore the strategy adoption probability is reduced by a
multiplicative factor (w < 1) from the players of type B. We report that the
motion of the influential payers (type A) can improve remarkably the
maintenance of cooperation even for their low densities.Comment: 7 pages, 7 figure
Mutual Events in the Cold Classical Transneptunian Binary System Sila and Nunam
Hubble Space Telescope observations between 2001 and 2010 resolved the binary
components of the Cold Classical transneptunian object (79360) Sila-Nunam
(provisionally designated 1997 CS29). From these observations we have
determined the circular, retrograde mutual orbit of Nunam relative to Sila with
a period of 12.50995 \pm 0.00036 days and a semimajor axis of 2777 \pm 19 km. A
multi-year season of mutual events, in which the two near-equal brightness
bodies alternate in passing in front of one another as seen from Earth, is in
progress right now, and on 2011 Feb. 1 UT, one such event was observed from two
different telescopes. The mutual event season offers a rich opportunity to
learn much more about this barely-resolvable binary system, potentially
including component sizes, colors, shapes, and albedo patterns. The low
eccentricity of the orbit and a photometric lightcurve that appears to coincide
with the orbital period are consistent with a system that is tidally locked and
synchronized, like the Pluto-Charon system. The orbital period and semimajor
axis imply a system mass of (10.84 \pm 0.22) \times 10^18 kg, which can be
combined with a size estimate based on Spitzer and Herschel thermal infrared
observations to infer an average bulk density of 0.72 +0.37 -0.23 g cm^-3,
comparable to the very low bulk densities estimated for small transneptunian
binaries of other dynamical classes.Comment: In press in Icaru
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